The interaction of nanoparticles with biological media {is a|is really a|is actually a|can be a|is often a|is usually a} {topic|subject} of {general|common|basic} interest for drug delivery systems and {among|amongst} {those|these} for active nanoparticles, also {called|known as|referred to as|named} nanomotors. Herein, we report {the use of|the usage of} super resolu-tion microscopy, in {particular|specific|certain|distinct|unique} stochastic optical reconstruction microscopy (STORM), to characterize the formation of protein corona {around|about} active enzyme-powered nanomotors. {First|Initial|Very first|1st|Initially}, we characterize the distribu-tion and {number|quantity} of enzymes on nano-sized particles and characterized their motion capabilities. Then, we incubated the nanomotors with fluorescently labelled serum proteins. Interestingly, we observed a signifi-cant {decrease|reduce|lower} of protein corona formation (20 %) and {different|various|distinct|diverse|unique|distinctive} composition, which was studied by a proteo-mic {analysis|evaluation}. {Moreover|Furthermore|In addition|Additionally}, motion was not hindered, as nanomotors displayed an enhanced diffusion {regardless of|no matter|irrespective of} protein corona. Elucidating how active particles interact with biological media and {maintain|preserve|sustain|keep|retain} their self-propulsion {after|following|right after|soon after|immediately after|just after} protein corona formation will pave the way {of the|from the|in the|on the|with the|of your} use these systems in {complex|complicated} biological fluids in biomedicine. Diphenylmethanimine Formula 147969-86-6 Chemscene PMID:24605203
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