{Typical|Common|Standard} photowitches interconvert {between|in between|among|amongst|involving} two {different|various|distinct|diverse|unique|distinctive} states by {simple|easy|straightforward|basic|uncomplicated|very simple} isomerization reactions, which represents a {fundamental|basic} limit for applications. To expand the switching capacity {usually|generally|typically|normally|commonly|ordinarily} {different|various|distinct|diverse|unique|distinctive} photoswitches {have to be|need to be} linked {together|with each other|collectively} {leading|top|major} to {strong|powerful|robust|sturdy} {increase|improve|boost|enhance|raise} in molecular weight, diminished switching function, and {less|much less|significantly less} precision and selectivity of switching events. Herein we present an {approach|method|strategy} for solving this {essential|important|crucial|vital|necessary|critical} {problem|issue|difficulty|dilemma|challenge|trouble} {with a|having a|using a} {different|various|distinct|diverse|unique|distinctive} photoswitching {concept|idea|notion}. A {basic|fundamental|simple|standard} molecular switch architecture {provides|offers|gives|supplies|delivers} precision photoswitching {between|in between|among|amongst|involving} eight {different|various|distinct|diverse|unique|distinctive} states {via|by way of|through|by means of} controlled rotations {around|about} {three|3} adjacent covalent bonds. All eight states {can be|may be|could be|might be|is often|is usually} populated {one|1|a single|one particular} {after|following|right after|soon after|immediately after|just after} {another|an additional|yet another|one more|a different|a further} in an eight-step cycle by alternating {between|in between|among|amongst|involving} photochemical Hula-Twist isomerizations and thermal single bond rotations. By {simply|merely|just|basically} {changing|altering} solvent and temperature {the same|exactly the same|the identical|precisely the same|the exact same} switch {can also|may also|also can} undergo a {different|various|distinct|diverse|unique|distinctive} cycle {instead|rather|as an alternative|alternatively} interconverting just {five|5} isomers {in a|inside a|within a} selective sequence. This behavior is enabled {through|via|by means of|by way of} the discovery of an unprecedented photoreaction, a {one|1|a single|one particular} photon dual single bond rotation. Azido-PEG8-acid web Formula of 7-Bromo-3-oxoisoindoline-4-carbonitrile PMID:23509865
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