Surface-enhanced Raman scattering (SERS) spectroscopy has been {used|utilized|employed|utilised|applied|made use of} extensively to study biology, chemistry, and {materials|supplies|components}. {However|Nevertheless|Nonetheless|Even so|On the other hand|Having said that}, a point-by-point SERS mapping is time-consuming, taking minutes to hours for large-scale imaging. {Here|Right here}, we report a wide-field surface-enhanced coherent anti-Stokes Raman scattering (WISE-CARS) microscopy for monitoring nanotags in {live|reside} cells and label-free detection of metabolic molecules. The WISE-CARS microscope achieves an imaging speed as {fast|quick|quickly|rapidly|rapid|speedy} as 120 frames per second {for a|to get a|for any} {large|big|huge|massive|substantial|significant} field of view of 130 microns X 130 microns. By spectral focusing of femtosecond lasers, a hyperspectral WISE-CARS stack of 120 frames {can be|may be|could be|might be|is often|is usually} acquired {with a|having a|using a} spectral resolution of {10|ten} cm-1, {where|exactly where} {over|more than} 1 million Raman spectra are parallelly recorded {within|inside} 0.{5|five} seconds. As applications, we demonstrate time-lapse, 3D WISE-CARS imaging of nanotags in {live|reside} cells {as well as|in addition to|along with|and also|together with|and} label-free detection of adenine released from S. aureus. Thiocarbonyldiimidazole In stock (S)-2-Methoxy-1-phenylethan-1-amine supplier PMID:24282960
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