We report the synthesis of monodisperse (i.e. discrete)polysarcosine compounds and their use as a hydrophobicitymasking entity for the {construction|building} of highly-loaded homogeneous β-glucuronidase-responsive antibody-drug conjugates (ADCs). Thehighly hydrophilic drug-linker platform described herein improvesdrug-loading, physicochemical properties, pharmacokinetics and invivo antitumor efficacy {of the|from the|in the|on the|with the|of your} resulting conjugates. 173841-05-9 Purity 2,6-Di(1-pyrazolyl)pyridine web PMID:32926338
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