A substrate-directed enantioselective anti-carboboration reaction of alkenes has been {developed|created}, wherein a carbon {based|primarily based} nucleophile {and a|along with a|as well as a|plus a|and also a|in addition to a} boron moiety are installed across the C=C bond {through|via|by means of|by way of} a 5- or 6-membered palladacycle intermediate. The reaction is promoted by a palladium(II) catalyst {and a|along with a|as well as a|plus a|and also a|in addition to a} mondentate oxzazoline ligand. A {range|variety} of enantioenriched secondary alkylboronate {products|goods|items|merchandise|solutions} {were|had been|have been} obtained with moderate to {high|higher} enantioselectivity that {could be|might be|could possibly be|may be|may very well be} {further|additional} upgraded by recrystallization. This {work|function|perform|operate} represents {a new|a brand new} {method|technique|approach|strategy|system|process} to synthesize versatile and {valuable|beneficial|useful|worthwhile|precious|important} alkylboronate {building|developing|creating|constructing} blocks. {Building|Developing|Creating|Constructing} on an earlier mechanistic proposal by Peng, He, and Chen, a revised model is proposed to account for the stereoconvergent nature of this transformation. 958451-91-7 custom synthesis 4-Bromo-5-fluoro-2-methylpyridine supplier PMID:25269910
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