{Live|Reside} cell surface functionalization has been increasingly explored in {recent|current} years {because of|due to|as a result of} its emerging bio- {medical|healthcare|health-related} and therapeutic applications. {Known|Recognized|Identified} {methods|techniques|strategies|approaches|procedures|solutions} to functionalize live-cell surface {includes|consists of|contains|involves|incorporates} time-consuming metabolic docking of non-natural functional groups on cell surfaces {that are|which are|which can be|which might be|that happen to be} {hard|difficult|tough|challenging|really hard} {to use|to make use of|to utilize|to work with}. {Here|Right here}, we report {an easy|a simple} and direct functionalization {method|technique|approach|strategy|system|process} for cell surface and cell-cell conjugation {utilizing|using} native phosphate groups on cell membranes. We {used|utilized|employed|utilised|applied|made use of} three-dimensional single-molecule localization microscopy to confirm that the chemical conjugate binds preferentially {on the|around the} cell surface. We show an application of this {method|technique|approach|strategy|system|process} for live-cell imaging and enhancement of cell-cell interaction {leading|top|major} to {increased|elevated|improved|enhanced} T cell proliferation. Our {simple|easy|straightforward|basic|uncomplicated|very simple} and reversible cell-conjugation {strategy|technique|method|approach|tactic} {would be|could be|will be} {widely|extensively|broadly} {useful|helpful|beneficial|valuable} to {explore|discover} and optimize cell-cell contact-based proliferation for any cell-based therapeutic applications. N-Boc-PEG6-alcohol site Benzene-1,2-dithiol Formula PMID:23771862
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