We report a mild, {fast|quick|quickly|rapidly|rapid|speedy} and {convenient|handy|hassle-free|practical|easy} catalytic {system|method|program|technique} for the coupling of aryl chlorides with {primary|main|major|principal|key}, secondary, {as well as|in addition to|along with|and also|together with|and} previously {challenging|difficult} tertiary alkyl thiols {using|utilizing|making use of|employing|working with|applying} an air-stable nickel(II) precatayst in {combination|mixture} {with the|using the|with all the|together with the} low-cost base potassium acetate at {room|space|area} temperature. This new catalytic {system|method|program|technique} tolerates {a variety of|a number of|many different|various|a range of|several different} functional groups and enables the generation of thioethers {for a|to get a|for any} wide {range of|selection of|array of} substrates, {including|such as|which includes|like} pharmaceutical compounds in {excellent|superb|outstanding|exceptional|great|fantastic} yields. Chemoselec-tive functionalization of disubstituted substrates was demonstrated. Kinetic and NMR-studies, {as well as|in addition to|along with|and also|together with|and} DFT computations {support|assistance|help} a Ni(0)/Ni(II) catalytic cycle and {identify|determine|recognize} the oxidative addition {product|item|solution} {as the|because the} resting state. Acetate coordination and subsequent acetate facilitated formation of a thiolate {complex|complicated} {via|by way of|through|by means of} internal deprotonation play a {key|important|crucial|essential} {role|function|part} {in the|within the|inside the} catalytic cycle. Triphenylbismuth uses 55241-49-1 Chemscene PMID:24189672
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