We introduce catalytic organic synthesis by Resonant Acoustic Mixing (RAM): a mechanochemical methodology that {does not|doesn’t|will not} {require|need|demand|call for} bulk solvent or milling media. {Using|Utilizing|Making use of|Employing|Working with|Applying} as model reactions ruthenium-catalyzed ring-closing metathesis, ene-yne metathesis and copper-catalyzed sulfonamide-isocyanate coupling, we demonstrate RAM-based mechanochemical synthesis {that is|that’s|which is|that is certainly|that is definitely|that may be} {faster|quicker|more quickly|more rapidly} and operationally {simpler|easier} than {conventional|standard|traditional} ball milling. {Moreover|Furthermore|In addition|Additionally}, the {method|technique|approach|strategy|system|process} {can be|may be|could be|might be|is often|is usually} readily scaled-up, as demonstrated by {straightforward|simple} catalytic synthesis {of the|from the|in the|on the|with the|of your} antidiabetic drug Tolbutamide from {hundreds of|a huge selection of|numerous} milligrams to {at least|a minimum of|at the very least|at the least|no less than} {10|ten} grams, {without|with out|without having|with no|devoid of|without the need of} any {significant|substantial|considerable|important} {changes|modifications|adjustments|alterations} in reaction {conditions|circumstances|situations}. 148256-82-0 Chemical name 957770-66-0 supplier PMID:23800738
Headquartered in New Jersey, USA, ChemScence is a global leading manufacturer and supplier of building blocks and fine research chemicals. We now have branches in Sweden and India. Our mission is to pave the way for drug discovery by providing the most innovative chemicals with the highest-level quality for a reasonable price.
Our Catalog Products
We deliver an extensive portfolio of products, including Building Blocks,Catalysts&Ligands,Synthetic Reagents,Material Science and ADC Linkers&Protac,.ChemScene now have over 600000 Building Blocks & Intermediates in our catalog and more than 70000 of them are in stock.
For details, please refer to the ChemScene website:https://www.chemscene.com