{Four|4} parthenolide derived prodrugs, containing {different|various|distinct|diverse|unique|distinctive} boronic ester moieties, {were|had been|have been} synthesised, their drug-like properties {were|had been|have been} calculated and their activity against chronic lymphocytic leukaemia (CLL) MEC1 cells measured. {Differences|Variations} {in the|within the|inside the} clogP, the propensity towards oxidation by hydrogen peroxide, the affinity {of the|from the|in the|on the|with the|of your} {associated|related|connected|linked} diols to a model boronic acid {and the|and also the|as well as the|along with the|plus the} biological activity against MEC1 cells {were|had been|have been} contrasted, and it was {found|discovered|identified|located} that the propensity for oxidation correlated to biological activity. 926659-01-0 Chemical name Grubbs 1st manufacturer PMID:24518703
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