Dynamically crosslinked gels are {appealing|attractive} {materials|supplies|components} for applications that {require|need|demand|call for} time-dependent mechanical responses. DNA duplexes are {ideal|perfect|best|excellent} crosslinkers for {building|developing|creating|constructing} such gels {because of|due to|as a result of} their {excellent|superb|outstanding|exceptional|great|fantastic} sequence addressability and {flexible|versatile} tunability in bond {energy|power}. {However|Nevertheless|Nonetheless|Even so|On the other hand|Having said that}, the mechanical responses of most DNA gels are {complicated|complex|difficult} and unpredictable {despite|regardless of|in spite of} the {high|higher} {potential|possible|prospective} of DNA. {Here|Right here}, we demonstrate a DNA gel {with a|having a|using a} {highly|extremely|very|hugely} homogeneous gel network and well-predictable mechanical behaviors {by using|by utilizing} a pair of star-polymer-DNA precursors with presimulated DNA sequences {showing|displaying} the two-state transition. The melting curve {analysis|evaluation} {of the|from the|in the|on the|with the|of your} DNA gels reveals the {good|great|excellent|very good|fantastic|superior} correspondence {between|in between|among|amongst|involving} the thermodynamic potentials {of the|from the|in the|on the|with the|of your} DNA crosslinkers {and the|and also the|as well as the|along with the|plus the} presimulated values by DNA calculators. Stress-relaxation tests and dissociation kinetics measurements show that the macroscopic relaxation time {of the|from the|in the|on the|with the|of your} DNA gels is {approximately|roughly|around|about} equal {to the|towards the|for the} lifetime {of the|from the|in the|on the|with the|of your} DNA crosslinkers {over|more than} {four|4} orders of magnitude from 0.1-2,000 sec. {Furthermore|Moreover|In addition|Additionally}, a series of durability tests {find|discover|locate|uncover|come across|obtain} the DNA gels are hysteresis-less and self-healable {after|following|right after|soon after|immediately after|just after} the applications of repeated temperature and mechanical stimuli. These {results|outcomes|final results|benefits} demonstrate the {great|fantastic|excellent|wonderful|good|terrific} {potential|possible|prospective} of star-polymer-DNA precursors for {building|developing|creating|constructing} gels with predictable and tunable viscoelastic properties, {suitable|appropriate} for applications {such as|like|including|for example|for instance|which include} stress-response extracellular matrices, injectable solids, and soft robotics. 170853-04-0 Order Buy1251013-26-9 PMID:36014399
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