The synthesis of phenoxazine dyes was revisited {in order to|to be able to|as a way to|in an effort to|so as to|so that you can} access these fluorescent N,O-heterocycles {under|below|beneath} mild {conditions|circumstances|situations}. The combined sequential use of nitrosonium tetrafluoroborate (NOBF4) and triphenylphosphine enables the facile conversion of bis(3-dimethylaminophenyl) ether {into the|in to the} methyl analog of {popular|well-liked|well-known|common|well known|preferred} laser dye oxazine 1. The {ability|capability|capacity|potential} of nitrosonium cation (NO+) to initiate the domino reaction resulting in pi-conjugated phenoxazine molecules {under|below|beneath} neutral {conditions|circumstances|situations}, then led us to {explore|discover} the feasibility of expanding it in aqueous media. {Thus|Therefore|Hence|As a result}, we explored {the use of|the usage of} reactive signaling molecule nitric oxide (NO) as a biological trigger of phenoxazine synthesis in water. The implementation of a robust analytical methodology {based|primarily based} on fluorescence assays and HPLC-fluorescence/-MS analyses, have enabled us to demonstrate the viability of this novel fluorogenic reaction-based {process|procedure|method|approach|course of action} to selectively yield an intense “OFF-ON” response {in the|within the|inside the} near-infrared (NIR-I) spectral {region|area}. This study {is an|is definitely an} {important|essential|crucial|critical|significant|vital} step towards the popularization {of the|from the|in the|on the|with the|of your} {concept|idea|notion} of “covalent-assembly” {in the|within the|inside the} fields of optical sensing, bioimaging and molecular theranostics. 88971-40-8 Chemscene 2-Ethynylpyrazine Chemical name PMID:35345980
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