We generalize the Kirkwood-Shumaker theory of protonisation fluctuation for an anisotropic distribution of dissociable charges on a globular protein. The fluctuations {of the|from the|in the|on the|with the|of your} total charge {and the|and also the|as well as the|along with the|plus the} total dipole moment, in contrast to their {average|typical} values, {depend on|rely on} {the same|exactly the same|the identical|precisely the same|the exact same} proton occupancy correlator, {thus|therefore|hence|as a result} exhibiting a {similar|comparable|equivalent|related} dependence also {on the|around the} {solution|answer|remedy|resolution|option} pH. This has {important|essential|crucial|critical|significant|vital} consequences for the Kirkwood-Shumaker interaction and its dependence {on the|around the} bathing {solution|answer|remedy|resolution|option} {conditions|circumstances|situations}. Buy914224-26-3 2621932-37-2 Chemscene PMID:23659187
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