The methoxy- and fluoro-derivatives of meta-nitrophenylacetic acid (mNPA) chromophores undergo photodecarboxylation with comparable quantum yields to unsubstituted mNPA, but uncage at red-shifted excitation wavelengths. This observation prompted us to investigate DPAdeCageOMe (2-[bis(pyridin-2-ylmethyl)amino]-2-(4-methoxy-3-nitrophenyl)acetic acid) and DPAdeCageF (2-[bis(pyridin-2-ylmethyl)amino]-2-(4-fluoro-3-nitrophenyl)acetic acid) as Zn2+ photocages. DPAdeCageOMe {has a|features a|includes a} {high|higher} quantum yield and exhibits other photophysical properties comparable to XDPAdeCage ({bis[(2-pyridyl)methyl]amino}(9-oxo-2-xanthenyl) acetic acid), {the best|the very best|the most effective|the top|the ideal|the most beneficial} perforiming Zn2+ photocage reported to date. {Since the|Because the} synthesis of DPAdeCageOMe is {more|much more|a lot more|far more|additional|extra} {straightforward|simple} than XDPACage, the new photocage {will be|will probably be|will likely be|is going to be|might be|are going to be} a {highly|extremely|very|hugely} competitive tool for biological applications. 1-(6-Bromonaphthalen-2-yl)ethanone Chemscene 5-Azidopentan-1-amine manufacturer PMID:34856019
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