The {ability to|capability to} reverse controlled radical polymerization and regenerate the monomer {would be|could be|will be} {highly|extremely|very|hugely} {beneficial|advantageous|helpful|useful|valuable|effective} for {both|each} {fundamental|basic} {research|study|analysis|investigation} and applications, {yet|however|but} has remained {very|extremely|really|quite|incredibly|pretty} {challenging|difficult} {to achieve|to attain}. Herein, we report a near-quantitative ({up to|as much as} 92%) and catalyst-free depolymerization of {various|numerous|different|a variety of|several|many} linear, bulky, crosslinked, and functional polymethacrylates {made|produced|created} by reversible addition-fragmentation chain-transfer (RAFT) polymerization. {Key|Important|Crucial|Essential} to our {approach|method|strategy} {is to|would be to|is always to|is usually to|will be to|should be to} exploit the {high|higher} end-group fidelity of RAFT polymers to {generate|produce|create} chain-end radicals {via|by way of|through|by means of} thermal homolytic cleavage of carbon-sulfur bond {of the|from the|in the|on the|with the|of your} RAFT end-group at 120 °C. These radicals trigger a {rapid|fast|speedy} unzipping of {both|each} {conventional|standard|traditional} (e.g. poly(methyl methacrylate)) and bulky polymers (e.g. poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA)). Importantly, the depolymerization {product|item|solution} {can be|may be|could be|might be|is often|is usually} utilized to either reconstruct the linear polymer or {create|produce|develop|generate|make|build} an {entirely|completely|totally} new insoluble gel {that can|that may|that will|that could|which will|which can} also be subjected to depolymerization. This {work|function|perform|operate} expands the {potential|possible|prospective} of polymers {made|produced|created} by CRP, pushes the boundaries of depolymerization, {offers|provides|gives|delivers|presents} intriguing mechanistic {aspects|elements}, and enables new applications. 3-Iodo-4-(trifluoromethyl)aniline web N-Fmoc-N’-methyl-L-asparagine Purity PMID:23399686
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