Structure {analysis|evaluation} of {small|little|tiny|modest|smaller|compact} crystals {is important|is essential|is very important|is vital|is significant} in synthetic organic chemistry, pharmaceutical and material sciences, and {related|associated|connected} {areas|locations|places|regions}, {as the|because the} conformation {of these|of those} molecules {may|might|could|may possibly|may well|may perhaps} differ in {large|big|huge|massive|substantial|significant} and {small|little|tiny|modest|smaller|compact} crystals, {thus|therefore|hence|as a result} affecting the interpretation of their functional properties and drug efficacy. From {small|little|tiny|modest|smaller|compact} crystals, X-ray and electron beams could furnish electron densities and Coulomb potentials of target molecules, respectively. The two beams {provide|offer|supply|give|present|deliver} distinctly {different|various|distinct|diverse|unique|distinctive} {information|info|details|data|facts|information and facts}, and this {potential|possible|prospective} has not been {fully|totally|completely} explored. {Here|Right here} we present the detailed structure of an organic molecule, rhodamine-6g by X-ray free-electron laser (XFEL) and electron crystallography {from the|in the} {same|exact same|identical|very same|similar} sample batch of microcrystals. {This is|This really is|This can be|That is} {the first|the very first|the initial} organic molecular structure determined {using|utilizing|making use of|employing|working with|applying} XFEL at subatomic resolution. Direct comparison {between|in between|among|amongst|involving} the electron-density {and the|and also the|as well as the|along with the|plus the} Coulomb-potential maps {together|with each other|collectively} with theoretical models {based on|according to|depending on|determined by} Poisson’s equation shows that the position of hydrogen atoms {depends on|depends upon|is determined by|is dependent upon|will depend on} bond {type|kind|sort|variety|form} and charge distribution. The combined {approach|method|strategy} could {lead to|result in|bring about|cause} {better|much better|far better|greater|superior|improved} insights into their chemical and/or binding properties {for a|to get a|for any} broad {range of|selection of|array of} organic molecules. 1,2-Dimethylhydrazine dihydrochloride web 1370535-33-3 uses PMID:23514335
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