This paper expands our {work|function|perform|operate} predicting {Process|Procedure|Method|Approach|Course of action} Mass Intensity (PMI), as a methodology for exploring the {potential|possible|prospective} efficiency of proposed synthetic routes. {In the|Within the|Inside the} present {work|function|perform|operate}, we integrate a {method|technique|approach|strategy|system|process} for predicting the PMI contributions of {high|higher} complexity reagents, {needed|required|necessary} to {enable|allow} {certain|particular|specific} transformations. We {focus|concentrate} on ligands for metal catalyzed reactions – and {develop|create} an {approach|method|strategy} for predicting which ligands {may|might|could|may possibly|may well|may perhaps} function in CN couplings – as a proof of {concept|idea|notion}. We leverage this to {enable|allow} the integration {of the|from the|in the|on the|with the|of your} PMI contribution {of the|from the|in the|on the|with the|of your} ligands into a predictions of a routes efficiency, enabling an understanding {of the|from the|in the|on the|with the|of your} holistic {impact|influence|effect} of a route {decision|choice|selection}.. 1035351-06-4 In stock 4,6-Dichloropyrimidin-5-amine Purity PMID:24059181
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