By {simply|merely|just|basically} adding water and sodium iodide (NaI) to chlorotrimethylsilane (TMSCl), promotion of a Vorbrüggen glycosylation en route to {essential|important|crucial|vital|necessary|critical} HIV drugs emtricitabine (FTC) and lamivudine (3TC) is {achieved|accomplished}. TMSCl-NaI in wet solvent (0.1 M water) activates a 1,3-oxathiolanyl acetate donor for N-glycosylation of silylated cytosine derivatives, {leading|top|major} to cis ox-athiolane {products|goods|items|merchandise|solutions} with {up to|as much as} 95% yield and >20:1 dr. This telescoped sequence is followed by recrystallization and borohydride reduction, resulting in {rapid|fast|speedy} synthesis of (±)-FTC/3TC from an achiral tartrate ester. Pyrazolo[1,5-a]pyridine-5-carboxaldehyde custom synthesis Formula of 951173-34-5 PMID:23903683
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