We report the {challenging|difficult} direct carbamoylation or cyanation of benzylic C(sp3)-H bonds with an isocyanide {via|by way of|through|by means of} an electrochemical {process|procedure|method|approach|course of action} {giving|providing} rise to structures {which are|that are} encountered in {several|a number of|numerous|many|various|quite a few} biologically relevant compounds and drugs. This transformation proceeds in mild {conditions|circumstances|situations} {without|with out|without having|with no|devoid of|without the need of} the {need|require|want|need to have|will need|have to have} of external oxidant and avoids the necessity {to start|to begin} from a prefunctionalized benzylic substrate or the deployment {of the|from the|in the|on the|with the|of your} cation pool {method|technique|approach|strategy|system|process}. Anodic oxidation {of the|from the|in the|on the|with the|of your} benzylic position and subsequent addition {of the|from the|in the|on the|with the|of your} isocyanide {leads to|results in} the formation of a C-C bond and to a nitrilium cation which hydrolysis {leads to|results in} alpha-aryl acetamide derivatives, {while|whilst|although|even though|when|though} elimination of a t-butyl cation delivers alpha-aryl acetonitrile derivatives. Lumisterol 3 (>90%) Data Sheet 3-Iodo-4-(trifluoromethyl)aniline site PMID:26760947
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