In {recent|current} years, mechanochemistry has enriched the toolbox of synthetic chemists, enabling {faster|quicker|more quickly|more rapidly} {and more|and much more} sustainable access to new {materials|supplies|components} and {existing|current} {products|goods|items|merchandise|solutions}, {including|such as|which includes|like} active pharmaceutical {ingredients|components} (APIs). {However|Nevertheless|Nonetheless|Even so|On the other hand|Having said that}, molecular-level understanding of most mechanochemical reactions remains {limited|restricted}, delaying the implementation of mechanochemistry in industrial applications. Herein, {we have|we’ve|we’ve got} applied in-situ monitoring by Raman spectroscopy {to the|towards the|for the} mechanosynthesis of phenytoin, a {World|Globe|Planet} {Health|Well being|Wellness|Overall health} Organization (WHO) {Essential|Important|Crucial|Vital|Necessary|Critical} Medicine, enabling the observation, isolation, and characterization of {key|important|crucial|essential} molecular-migration intermediates involved {in the|within the|inside the} single-step transformation of benzil, urea, and KOH into phenytoin. This {work|function|perform|operate} contributes {to the|towards the|for the} elucidation of a reaction mechanism {that has|which has} been subjected to {a number of|numerous|several|quite a few|a variety of|many} interpretations {over time|as time passes|with time} and paints a clear {picture|image} of how mechanosynthesis {can be|may be|could be|might be|is often|is usually} applied and optimized for the preparation of added-value molecules. BuyTrifluridine Price of Lenalidomide-Br PMID:23546012
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