Metal-mediated base pairs are formed by the connection of two nucleobases {via|by way of|through|by means of} coordination to a metal cation. The resulting metal-containing duplexes {have been|happen to be|have already been} {used|utilized|employed|utilised|applied|made use of} {in a|inside a|within a} {large|big|huge|massive|substantial|significant} {variety of|number of|selection of} applications ranging from allosteric {control|manage|handle} of functional nucleic acids {to the|towards the|for the} {construction|building} of nanowires. {Recently|Lately|Not too long ago}, enzymatic approaches are {being|becoming|getting} {developed|created} for the {construction|building} of metal-mediated base pairs. {Here|Right here}, {we have|we’ve|we’ve got} studied the possibility of constructing HgII- and AgI-mediated DNA/RNA hetero base pairs {using|utilizing|making use of|employing|working with|applying} primer extension reactions. The {high|higher} kinetic and thermodynamic stabilities of metal base pairs {can be|may be|could be|might be|is often|is usually} harnessed to trigger the formation of {multiple|numerous|several|a number of|many|various} rU-HgII-dT base pairs. 150529-93-4 site 1207294-92-5 Chemscene PMID:24377291
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