Dynamic nuclear polarization {utilizing|using} photoexcited triplet electrons (triplet-DNP) has {great|fantastic|excellent|wonderful|good|terrific} {potential|possible|prospective} for room-temperature hyperpolarization of nuclear spins. {However|Nevertheless|Nonetheless|Even so|On the other hand|Having said that}, the polarization transfer to molecules of interest remains a challenge {due to|because of|as a result of|on account of|resulting from|as a consequence of} the {fast|quick|quickly|rapidly|rapid|speedy} spin relaxation and weak interaction with target molecules at {room|space|area} temperature in {conventional|standard|traditional} host {materials|supplies|components}. {Here|Right here}, we demonstrate {the first|the very first|the initial} {example|instance} of DNP of guest molecules {in a|inside a|within a} porous material at {around|about} {room|space|area} temperature by {utilizing|using} the induced-fit-type structural transformation of a crystalline {yet|however|but} {flexible|versatile} metal-organic framework (MOF). In contrast {to the|towards the|for the} usual hosts, 1H spin-lattice relaxation time becomes longer by accommodating a pharmaceutical model target 5-fluorouracil {as the|because the} {flexible|versatile} MOF {changes|modifications|adjustments|alterations} its structure upon guest accommodation to maximize the host-guest interactions. Combined with triplet-DNP and cross-polarization, this {system|method|program|technique} realizes an enhanced 19F-NMR signal of guest target molecules at {around|about} {room|space|area} temperature. Imidazo[1,2-a]pyridine-8-carbaldehyde supplier Potassium tetrachloroplatinate(II) Data Sheet PMID:34235739
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