The {combination|mixture} of next-generation DNA sequencing technologies and bioinformatics have revitalized {natural|all-natural|organic} {product|item|solution} discovery. {Using|Utilizing|Making use of|Employing|Working with|Applying} {a new|a brand new} bioinformatic search {strategy|technique|method|approach|tactic}, we {recently|lately|not too long ago} identified ~600 gene clusters in animal microbiomes that code for ribosomal peptide {natural|all-natural|organic} {products|goods|items|merchandise|solutions} synthesized by radical S-adenosylmethionine enzymes. These grouped into 16 subfamilies and pointed to an unexplored microbiome biosynthetic landscape. Herein, we report the structure, biosynthesis, and function of {one|1|a single|one particular} {of these|of those} {natural|all-natural|organic} {product|item|solution} groups, that we term enteropeptins, {from the|in the} gut microbe Enterococcus cecorum. We elucidate {three|3} novel reactions, {each|every|each and every|every single} catalyzed by a {different|various|distinct|diverse|unique|distinctive} {family|family members|loved ones|household} of metalloenzymes, {in the|within the|inside the} biosynthesis of enteropeptins. {Among|Amongst} these, we characterize the founding member of a widespread superfamily of Fe-S-containing methyltransferases, which, {together|with each other|collectively} {with a|having a|using a} di-Mn-dependent arginase, installs an N-methylornithine {in the|within the|inside the} peptide sequence. Biological assays {with the|using the|with all the|together with the} mature {product|item|solution} revealed bacteriostatic activity only against the {producing|creating|generating|making} strain, extending an emerging theme of fratricidal or self-inhibitory metabolites in microbiome firmicutes. Bis(triphenylphosphine)dichloropalladium Chemscene Oxychlororaphine structure PMID:23514335
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