A Chemo- and Regioselective Tandem [3+2]Heteroannulation {Strategy|Technique|Method|Approach|Tactic} for Carbazole Synthesis: Synergizing Two Mechanistically Distinct Bond-Forming Processes

A modular {approach|method|strategy} to prepare tri- and tetracyclic carbazoles by a sequential heteroannulation is described. {First|Initial|Very first|1st|Initially}, op-timization of a Pd-catalyzed Buchwald-Hartwig amination followed by C/N-arylation {in a|inside a|within a}…

Pseudo High-Throughput {Development|Improvement} and Optimization {of the|from the|in the|on the|with the|of your} Electrochemical Oxidation of Sensitive Propargylic Benzylic Alco-hols

The electrochemical oxidation of sensitive propargylic benzylic alcohols {having|getting|possessing|obtaining} varying substituents is reported. The ther-mal oxidation of propargylic benzylic alcohols presents an acute challenge {in the|within the|inside the} synthesis of…

LimF {is a|is really a|is actually a|can be a|is often a|is usually a} versatile prenyltransferase catalyzing histidine-C-geranylation on diverse nonnatural substrates

Prenylation plays {an important|an essential|a crucial|a vital} {role|function|part} in diversifying structure and function of secondary metabolites. {Although|Even though|Though|Despite the fact that|While} {several|a number of|numerous|many|various|quite a few} cyanobactin prenyltransferases {have been|happen…

Comparison of coarse-grained and all-atomrepresentations by explicit {energy|power} landscapeexplorations

Computational {studies|research} of {large|big|huge|massive|substantial|significant} molecular systems are {often|frequently|usually|typically|generally|normally} hindered by resource constraints, {such as|like|including|for example|for instance|which include} the {available|accessible|obtainable|offered|readily available|out there} computational time. A {common|typical|frequent|widespread|prevalent|popular} {approach|method|strategy} to {reduce|decrease|minimize|lessen|lower|cut down} the…

Triplet Dynamic Nuclear Polarization of Guest Molecules {through|via|by means of|by way of} Induced {Fit|Match} {in a|inside a|within a} {Flexible|Versatile} Metal-Organic Framework

Dynamic nuclear polarization {utilizing|using} photoexcited triplet electrons (triplet-DNP) has {great|fantastic|excellent|wonderful|good|terrific} {potential|possible|prospective} for room-temperature hyperpolarization of nuclear spins. {However|Nevertheless|Nonetheless|Even so|On the other hand|Having said that}, the polarization transfer to molecules of…

Synthesis of {5|five}, {6|six}, 11, 12-tetrahyroindolo[3,2-b]carbazole-based dicarboxylate acid for MOFs fabrication {via|by way of|through|by means of} in-situ oxidative dehydrogenation

The indolocarbazole derivatives has been shown {great|fantastic|excellent|wonderful|good|terrific} potentials as {one of the|among the|one of many|one of several|among the list of|on the list of} {key|important|crucial|essential} {important|essential|crucial|critical|significant|vital} compounds {in the|within the|inside the}…

{Learning|Studying|Understanding|Finding out|Mastering} from Failure: Predicting Electronic Structure Calculation Outcomes with Machine {Learning|Studying|Understanding|Finding out|Mastering} Models

High-throughput computational screening for chemical discovery mandates the automated and unsupervised simulation of {thousands of|a large number of|a huge number of} new molecules and {materials|supplies|components}. In {challenging|difficult} {materials|supplies|components} spaces, {such…