A concise and {practical|sensible} synthesis has been {developed|created} {to provide|to supply} the 8-fluoro-5-hydroxy-3,4-diydrocarbostyril (8-FDC) fragment of OPC-167832 in 41 % yield and in > 99 % purity {over|more than} {4|four} {steps|actions|measures|methods} from 3-amino-4-fluorophenol. PMID:24914310 1,10-Phenanthroline-5,6-dione Data Sheet Buy1060816-50-3 The {key|important|crucial|essential} {feature|function} of this {process|procedure|method|approach|course of action} {is the|will be the|may be the|would be the|could be the|is definitely the} {development|improvement} of a telescoped {one|1|a single|one particular} pot synthesis {of the|from the|in the|on the|with the|of your} quinolone {via|by way of|through|by means of} a chemoselective amidation and {easier|simpler|less difficult|less complicated|much easier|a lot easier} {product|item|solution} isolation {without|with out|without having|with no|devoid of|without the need of} the {need|require|want|need to have|will need|have to have} {for a|to get a|for any} column chromatography.
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