Gold(I) complexes of {a new|a brand new} chiral phosphoric acid functionalized phosphine {of the|from the|in the|on the|with the|of your} CPA-Phos series {enable|allow} the enantioselective multicomponent reactions {between|in between|among|amongst|involving} aldehydes, hydroxylamines and cyclic yne-enones, {leading|top|major} to {3|three},4-dihydro-1H-furo[3,4-d][1,2]oxazines. This represents {the first|the very first|the initial} {example|instance} of {highly|extremely|very|hugely} enantioselective multicomponent reaction in gold(I) catalysis. The reactions proceed at low catalyst loading, {provide|offer|supply|give|present|deliver} {high|higher} yields, total diastereoselectivity and enantiomeric excesses {up to|as much as} 99%. Silver-free {conditions|circumstances|situations} {can be|may be|could be|might be|is often|is usually} applied. The {method|technique|approach|strategy|system|process} {has a|features a|includes a} {very|extremely|really|quite|incredibly|pretty} broad scope, {as it|because it|since it} applies to {both|each} aliphatic and aromatic aldehydes and hydroxylamines, to {a variety of|a number of|many different|various|a range of|several different} cyclic yne-enones, {as well as|in addition to|along with|and also|together with|and} to yne-enone derived oximes. DFT calculations are reported that enlighten the enantiocontrol pathway. Price of 6144-78-1 Buy6-Bromo-3-methoxy-1H-indazole PMID:35227773
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