Synthesis of α-heterosubstituted ketones was {achieved|accomplished} {through|via|by means of|by way of} sulfur mediated difunctionalization of internal alkynes in one-pot. The reaction {design|style|design and style} {involves|entails|requires|includes}: phenyl substituted internal alkyne attacking the triflic anhydride activated diphenyl sulfoxide {to give|to provide|to offer} a sulfonium vinyl triflate intermediate, hydrolysis {to give|to provide|to offer} the α-sulfonium ketone, {and then|and after that|after which|then} substitution with {various|numerous|different|a variety of|several|many} nucleophiles. This {method|technique|approach|strategy|system|process} {provides|offers|gives|supplies|delivers} a unified route to access α-amino ketones, α-acyloxy ketones, α-thio ketones, α-halo ketones, α-hydroxy ketones, and {related|associated|connected} heterocyclic structures, {in a|inside a|within a} {rapid|fast|speedy} {fashion|style}. (2-Cyanopyridin-3-yl)boronic acid Data Sheet 5-Chloro-1-ethyl-4-nitro-1H-imidazole structure PMID:23546012
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