{A new|A brand new} series of simplified azasordarin analogs was synthesized {using|utilizing|making use of|employing|working with|applying} as {key|important|crucial|essential} {steps|actions|measures|methods} a Diels-Alder reaction to {generate|produce|create} a {highly|extremely|very|hugely} substituted bicyclo[2.{2|two}.1]heptane core, followed by a subsequent nitrile alkylation. {Several|A number of|Numerous|Many|Various|Quite a few} {additional|extra|further|added|more} {strategies|methods|techniques|approaches|tactics} {were|had been|have been} investigated for the generation {of the|from the|in the|on the|with the|of your} {key|important|crucial|essential} tertiary nitrile or aldehyde {thought|believed} {to be|to become} {required|needed|necessary|essential|expected} for activity {at the|in the} fungal protein eukaryotic elongation {factor|aspect|element|issue} {2|two}. This new series also {features|attributes|functions|characteristics|capabilities|options} a morpholino glycone previously reported in semisynthetic sordarin derivatives with broad spectrum antifungal activity. {Despite|Regardless of|In spite of} a lack of activity against C. albicans for these early de novo analogs, the synthetic route reported {here|right here} permits {more|much more|a lot more|far more|additional|extra} {comprehensive|complete|extensive} modifications {of the|from the|in the|on the|with the|of your} bicyclic core, and SAR {studies|research} that {were|had been|have been} not heretofore {possible|feasible|achievable|attainable|doable|probable}. AN-12-H5 intermediate-1 Chemical name Formula of 1239591-03-7 PMID:35991869
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