The {potential|possible|prospective} of antibody conjugates with {high|higher} drug loading in anticancer therapy has {recently|lately|not too long ago} been highlighted by the approval of Trastuzumab deruxtecan and Sacituzumab govitecan. These biopharmaceutical approaches have spurred interest in bioconjugation {strategies|methods|techniques|approaches|tactics} with {high|higher} and defined degrees antibody-to-drug (DAR) ratios, in {particular|specific|certain|distinct|unique} on native antibodies. {Here|Right here} we report a glycoengineering methodology to {generate|produce|create} antibody drug conjugates with DAR of {up to|as much as} eight, by combining {highly|extremely|very|hugely} selective enzymatic galactosylation and oxidation with biorthogonal tandem Knoevenagel-Michael addition chemistry. This {three|3} step {approach|method|strategy} {offers|provides|gives|delivers|presents} a selective route to conjugates from native antibodies with {high|higher} drug loading, and {thus|therefore|hence|as a result} illustrates how biocatalysis {can be|may be|could be|might be|is often|is usually} {used|utilized|employed|utilised|applied|made use of} for the generation of biopharmaceuticals {using|utilizing|making use of|employing|working with|applying} mild reaction {conditions|circumstances|situations}. Fmoc-Lys-OH (hydrochloride) web (R)-JQ-1 (carboxylic acid) web PMID:28440459
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