This paper describes nanopore decoding for microRNA (miRNA) expression patterns {using|utilizing|making use of|employing|working with|applying} DNA computing {technology|technologies}. miRNAs have shown {promise|guarantee} as markers for cancer diagnosis {due to|because of|as a result of|on account of|resulting from|as a consequence of} their cancer type-specificity, and {therefore|consequently|as a result|for that reason|thus|hence} {simple|easy|straightforward|basic|uncomplicated|very simple} {strategies|methods|techniques|approaches|tactics} for miRNA-pattern recognition are {required|needed|necessary|essential|expected}. We propose a {system|method|program|technique} for pattern recognition of {five|5} {types|kinds|varieties|sorts|forms} of miRNAs overexpressed in bile duct cancer (BDC). The {information|info|details|data|facts|information and facts} of miRNAs from BDC is encoded in diagnostic DNAs (dgDNAs) and decoded electrically by nanopore measurement. With this {system|method|program|technique}, we succeeded in distinguishing miRNA expression patterns {in the|within the|inside the} plasma of BDC {patients|individuals|sufferers} {using|utilizing|making use of|employing|working with|applying} a label-free {method|technique|approach|strategy|system|process} and in real-time. {Moreover|Furthermore|In addition|Additionally}, our dgDNA-miRNAs complexes {can be|may be|could be|might be|is often|is usually} captured by the nanopore at ultralow concentration, {such as|like|including|for example|for instance|which include} 0.1 fM. Such nanopore decoding with dgDNAs {could be|might be|could possibly be|may be|may very well be} applied as a {simple|easy|straightforward|basic|uncomplicated|very simple} and early diagnostic tool for cancer {in the|within the|inside the} future. 165894-07-5 Price 6-Bromo-1H-indazole-3-carbonitrile Data Sheet PMID:24013184
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