A multi-component {approach|method|strategy} to structurally {complex|complicated} organosulfur {products|goods|items|merchandise|solutions} is described {via|by way of|through|by means of} the nickel-catalyzed 1,2-carbosulfenylation of unactivated alkenes with organoboron nucleophiles and tailored organosulfur electrophiles. {Key|Important|Crucial|Essential} {to the|towards the|for the} {development|improvement} of this transformation {is the|will be the|may be the|would be the|could be the|is definitely the} identification of a modular N-alkyl-N-(arylsulfenyl)arenesulfonamide {family|family members|loved ones|household} of sulfur electrophiles. Tuning the electronic and steric properties {of the|from the|in the|on the|with the|of your} leaving group in these reagents controls pathway selectivity, favoring three-component coupling and suppressing side reactions, as examined {via|by way of|through|by means of} computational {studies|research}. The {unique|distinctive|special|exclusive|exceptional|one of a kind} syn-stereoselectivity differs from {traditional|conventional|standard|classic|regular} electrophilic sulfenyl transfer processes involving a thiiranium ion intermediate and arises {from the|in the} directed arylnickel(I) migratory insertion mechanism, as elucidated {through|via|by means of|by way of} reaction kinetics and {control|manage|handle} experiments. Reactivity and regioselectivity are facilitated by a collection of monodentate, weakly coordinating native directing groups, {including|such as|which includes|like} sulfonamides, alcohols, amines, amides, and azaheterocycles. 41102-25-4 structure Fmoc-D-Isoleucine Order PMID:24428212
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