Organometallic intermediates {participate in|take part in} {many|numerous|several|a lot of|quite a few|lots of} multi-catalytic enantioselective transformations directed by a chiral catalyst, {but the|however the} requirement of optimizing two catalyst {components|elements} {is a|is really a|is actually a|can be a|is often a|is usually a} {significant|substantial|considerable|important} barrier to {widely|extensively|broadly} adopting this {approach|method|strategy} for chiral molecule synthesis. Algorithms can potentially accelerate the screening {process|procedure|method|approach|course of action} by {developing|creating|building|establishing} quantitative structure-function relationships from {large|big|huge|massive|substantial|significant} experimental datasets. {However|Nevertheless|Nonetheless|Even so|On the other hand|Having said that}, the chemical {data|information} {available|accessible|obtainable|offered|readily available|out there} {in this|within this} catalyst space is {limited|restricted}. We report a data-driven {strategy|technique|method|approach|tactic} that {effectively|successfully|efficiently|properly|proficiently|correctly} translates selectivity relationships {trained|educated} on enantioselectivity outcomes derived from {one|1|a single|one particular} catalyst reaction systems {where|exactly where} an abundance of {data|information} exists, to synergistic catalyst space. We describe {three|3} case {studies|research} involving {different|various|distinct|diverse|unique|distinctive} modes of catalysis (Brønsted acid, chiral anion, and secondary amine) that substantiate the prospect of this {approach|method|strategy} to predict and elucidate selectivity in reactions {where|exactly where} {more|much more|a lot more|far more|additional|extra} than {one|1|a single|one particular} catalyst is involved. {Ultimately|In the end|Eventually}, the {success|achievement|good results|accomplishment|results} in applying our {approach|method|strategy} to diverse {areas|locations|places|regions} of asymmetric catalysis implies that this {general|common|basic} workflow {should|ought to|must|need to|really should|should really} {find|discover|locate|uncover|come across|obtain} broad use {in the|within the|inside the} study and {development|improvement} of new enantioselective, multi-catalytic processes. 2-Aminopropanenitrile hydrochloride uses Formula of DBCO-C6-acid PMID:35991869
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