{Despite|Regardless of|In spite of} the {enormous|huge|massive} developments of asymmetric catalysis, the basis for asymmetric induction is largely {limited|restricted} to spatial interaction {between|in between|among|amongst|involving} substrate and catalyst. Consequently, asymmetric discrimination {between|in between|among|amongst|involving} two sterically {similar|comparable|equivalent|related} groups remains a challenge. {This is|This really is|This can be|That is} {particularly|especially|specifically} formidable for enantiodifferentiation {between|in between|among|amongst|involving} aryl and heteroaryl groups {without|with out|without having|with no|devoid of|without the need of} a directing group or electronic manipulation. {Here|Right here} we address this challenge by a robust organocatalytic {system|method|program|technique} {leading|top|major} to {excellent|superb|outstanding|exceptional|great|fantastic} enantioselection {between|in between|among|amongst|involving} aryl and heteroaryl groups. {With the|Using the|With all the|Together with the} versatile 2-indole imine methide as platform, {an excellent|a great|a superb|a fantastic} {combination|mixture} of a {superb|excellent} chiral phosphoric acid {and the|and also the|as well as the|along with the|plus the} optimal hydride {source|supply} {provided|supplied|offered} {efficient|effective} access to a {range of|selection of|array of} {highly|extremely|very|hugely} enantioenriched indole-containing triarylmethanes. {Control|Manage|Handle} experiments and kinetic {studies|research} {provided|supplied|offered} {important|essential|crucial|critical|significant|vital} insights {into the|in to the} mechanism. DFT calculations also indicated that, {while|whilst|although|even though|when|though} hydrogen bonding {is important|is essential|is very important|is vital|is significant} for activation, the {key|important|crucial|essential} interaction for discrimination {of the|from the|in the|on the|with the|of your} two aryl groups is {mainly|primarily|mostly} π-π stacking. Preliminary biological {studies|research} also demonstrated the {great|fantastic|excellent|wonderful|good|terrific} {potential|possible|prospective} {of these|of those} triarylmethanes for anticancer and antiviral drug {development|improvement}. Pyrene-4,5,9,10-tetraone Chemscene Buy(S)-3-Bromo-2-(1-methoxyethyl)pyridine PMID:23329319
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