Aromaticity {is one of the|is among the|is amongst the} most intriguing {concepts|ideas} in organic chemistry. {Simple|Easy|Straightforward|Basic|Uncomplicated|Very simple} and extended benzenoid aromatic systems {have been|happen to be|have already been} {very|extremely|really|quite|incredibly|pretty} {well|nicely|effectively|properly} established in undergraduate textbooks, and {there are|you will find|you’ll find|you can find|you will discover|there are actually} also mentions of non-benzenoid aromatic structures {such as|like|including|for example|for instance|which include} cyclopropenium, cyclopentadienide and cycloheptatrienylium (tropylium) ions. {However|Nevertheless|Nonetheless|Even so|On the other hand|Having said that}, the structural {relationship|partnership|connection} {and the|and also the|as well as the|along with the|plus the} comparison of stabilization {energy|power} of such aromatic ions to benzene ring {have been|happen to be|have already been} {rarely|seldom|hardly ever} studied and remained an underexplored {area|region|location} of {advanced|sophisticated} organic chemistry {research|study|analysis|investigation}. To contribute some insights into this {topic|subject}, we focused {on the|around the} chemical transformation, namely a ring contraction reaction, {of the|from the|in the|on the|with the|of your} tropylium ion to benzene ring {in this|within this} {work|function|perform|operate}. With an {approach|method|strategy} combining computational {studies|research} with experimental reactions, we also aim to turn this transformation into a synthetically {useful|helpful|beneficial|valuable} tool. {Indeed|Certainly}, this {work|function|perform|operate} led {to the|towards the|for the} {development|improvement} of {a new|a brand new} synthetic protocol, which involved an oxidative ring-contraction of tropylium ion, to formally introduce the phenyl ring onto a {range of|selection of|array of} organic structures. {Furthermore|Moreover|In addition|Additionally}, the homoaromatic cycloheptatrienyl precursors of tropylium salts {used|utilized|employed|utilised|applied|made use of} in these reactions {can also|may also|also can} be rearranged to {valuable|beneficial|useful|worthwhile|precious|important} benzhydryl or benzyl halides, enriching the synthetic utility of this ring-contraction protocol. Pyrrolidine Hydrochloride uses Price of 889944-72-3 PMID:24103058
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