Molecular dynamics with constrained nuclear electronic orbital density functional theory: {Accurate|Correct|Precise} vibrational spectra from {efficient|effective} incorporation of nuclear quantum effects

Nuclear quantum effects play a {crucial|essential|vital|critical|important} {role|function|part} in {many|numerous|several|a lot of|quite a few|lots of} chemical and biological systems involving hydrogen atoms {yet|however|but} are {difficult|tough|challenging|hard|tricky|complicated} to {include|consist of|contain|incorporate|include things like|involve} in…

DrugEx v3: Scaffold-Constrained Drug {Design|Style|Design and style} with Graph Transformer-based Reinforcement {Learning|Studying|Understanding|Finding out|Mastering}

{Due to|Because of|As a result of|On account of|Resulting from|As a consequence of} the {large|big|huge|massive|substantial|significant} drug-like chemical space {available|accessible|obtainable|offered|readily available|out there} to {search for|look for} feasible drug-like molecules, rational drug {design|style|design…

Independent gradient model {based on|according to|depending on|determined by} Hirshfeld partition (IGMH): {A new|A brand new} {method|technique|approach|strategy|system|process} for visual study of interactions in chemical systems

The independent gradient model (IGM) {originally|initially} proposed in Phys. Chem. Chem. Phys., 19, 17928 (2017) has been increasingly {popular|well-liked|well-known|common|well known|preferred} in visual {analysis|evaluation} of intramolecular and intermolecular interactions in {recent|current}…

A minimalist {approach|method|strategy} to protein identification

This {work|function|perform|operate} demonstrates a minimal single-molecule proteolysis-free {approach|method|strategy} that {requires|demands|needs|calls for} {very|extremely|really|quite|incredibly|pretty} {small|little|tiny|modest|smaller|compact} samples, is non-destructive, {and can|and may} be translated with {currently|presently|at present|at the moment} {available|accessible|obtainable|offered|readily available|out there} {technology|technologies}…