{While|Whilst|Although|Even though|When|Though} {developing|creating|building|establishing} boron-catalyzed glycosylations {using|utilizing|making use of|employing|working with|applying} glycosyl fluoride donors and trialkylsilyl ether acceptors, competing pathways involving productive glycosylation or glycosyl exchange {were|had been|have been} observed. Experimental and computational mechanistic {studies|research} {suggest|recommend} a novel mode of reactivity {where|exactly where} a dioxolenium ion {is a|is really a|is actually a|can be a|is often a|is usually a} {key|important|crucial|essential} intermediate that promotes {both|each} pathways {through|via|by means of|by way of} addition to either a silyl ether or {to the|towards the|for the} acetal of an {existing|current} glycosidic linkage. Modifications in catalyst structure {enable|allow} either pathway {to be|to become} favored, and with this understanding, {improved|enhanced} multicomponent iterative couplings and glycosyl exchange processes {were|had been|have been} demonstrated. Methyl 1H-1,2,3-triazole-4-carboxylate Chemscene Buy4-Bromo-3-ethylbenzonitrile PMID:35227773
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