Herein, we report an iridium-catalyzed directed C−H amination methodology {developed|created} {using|utilizing|making use of|employing|working with|applying} a high-throughput experimentation (HTE)-based {strategy|technique|method|approach|tactic}, applicable for the {needs|requirements|wants|demands|desires|requires} of automated {modern|contemporary|modern day} drug discovery. The informer library {approach|method|strategy} for investigating accessible directing group chemical space for the reaction, in {combination|mixture} with functional group tolerance screening and substrate scope investigations, {allowed|permitted} for the generation of an empirical predictive model to guide future {users|customers}. Applicability to late-stage functionalization of {complex|complicated} drugs and {natural|all-natural|organic} {products|goods|items|merchandise|solutions}, in {combination|mixture} with {multiple|numerous|several|a number of|many|various} deprotection protocols {leading|top|major} {to the|towards the|for the} desirable aniline matched pairs, serve to demonstrate the utility {of the|from the|in the|on the|with the|of your} {method|technique|approach|strategy|system|process} for drug discovery. {Finally|Lastly|Ultimately} reaction miniaturization to a nano molar {range|variety} highlights the {opportunities|possibilities} for {more|much more|a lot more|far more|additional|extra} sustainable screening with decreased material consumption. 1629658-18-9 uses 3-Methoxy-4-pyridinamine custom synthesis PMID:24324376
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