The union of two {powerful|potent|effective|strong|highly effective} transformations, directed C–H activation and decarboxylative cross-coupling, for theenantioselective synthesis of vicinally functionalized alkyl, carbocyclic, and heterocyclic compounds is described. {Starting|Beginning} fromsimple carboxylic acid {building|developing|creating|constructing} blocks, this modular sequence exploits the residual directing group to access {more|much more|a lot more|far more|additional|extra} than 50 scaffoldsthat {would be|could be|will be} otherwise {extremely|very|incredibly|really|particularly|exceptionally} {difficult|tough|challenging|hard|tricky|complicated} to prepare. The tactical use {of these|of those} two transformations accomplishes a formal vicinaldifunctionalization of carbon centers {in a|inside a|within a} way {that is|that’s|which is|that is certainly|that is definitely|that may be} modular and {thus|therefore|hence|as a result} amenable to {rapid|fast|speedy} diversity incorporation. A simplification ofroutes to {known|recognized|identified} preclinical drug candidates is presented {along with|together with|in addition to|as well as|in conjunction with} the {rapid|fast|speedy} diversification of an antimalarial compound series. Phenylboronic acid custom synthesis P(t-Bu)3 Pd G2 Chemscene PMID:35126464
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