The biodistribution of chemotherapy compounds {within|inside} tumor tissue {is one of the|is among the|is amongst the} {main|primary|principal|major|key|most important} challenges {in the|within the|inside the} {development|improvement} of antineoplastic drugs, and novel {techniques|methods|strategies|tactics|approaches|procedures} for {simple|easy|straightforward|basic|uncomplicated|very simple}, non-expensive, sensitive, and selective detection of {various|numerous|different|a variety of|several|many} analytes in tumors are of {great|fantastic|excellent|wonderful|good|terrific} {importance|significance|value}. {In this|Within this} paper we propose {the use of|the usage of} platinized carbon nanoelectrodes (PtNE) for electrochemical detection of platinum-based drugs in {various|numerous|different|a variety of|several|many} biological models, {including|such as|which includes|like} single cells and tumor spheroids in vitro, and inside {solid|strong} tumors in vivo. {We have|We’ve|We’ve got} demonstrated quantitative direct detection of Pt(II) in breast adenocarcinoma MCF-7 cells treated with cisplatin and cisplatin-based DNP prodrug. To {realize|understand|recognize|comprehend} the {potential|possible|prospective} of this {technique|method|approach|strategy} in {advanced|sophisticated} tumor models, we measured Pt(II) in 3D tumor spheroids in vitro and tumor-bearing mice in vivo. The concentration gradient of Pt (II) species correlated {with the|using the|with all the|together with the} distance {from the|in the} sample surface in MCF-7 tumor spheroids. We then performed detection of Pt(II) species in tumor-bearing mice treated intravenously with cisplatin and DNP. We {found|discovered|identified|located} that there was deeper penetration of DNP in comparison to cisplatin. This {research|study|analysis|investigation} demonstrates a novel minimally invasive, real-time electrochemical {technique|method|approach|strategy} for the study of platinum-based drugs. 3-Acrylamidobenzoic acid Chemical name 3,4-Diethylhexane-3,4-diol manufacturer PMID:24406011
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