Unraveling the complexity of biological systems relies {on the|around the} {development|improvement} of new approaches for spatially resolved proteoform-specific {analysis|evaluation} {of the|from the|in the|on the|with the|of your} proteome. Herein, we employ nanospray desorption electrospray ionization mass spectrometry imaging (nano-DESI MSI) for the proteoform-selective imaging of biological tissues. Nano-DESI generates multiply charged protein ions, {which is|that is|which can be} advantageous for their structural characterization {using|utilizing|making use of|employing|working with|applying} tandem mass spectrometry (MS/MS) {directly|straight} {on the|around the} tissue. Proof-of-concept experiments demonstrate that nano-DESI MSI combined with on-tissue top-down proteomics is ideally suited for the proteoform-selective imaging of tissue sections. {Using|Utilizing|Making use of|Employing|Working with|Applying} rat brain tissue as a model {system|method|program|technique}, we {provide|offer|supply|give|present|deliver} {the first|the very first|the initial} {evidence|proof} of differential proteoform expression in {different|various|distinct|diverse|unique|distinctive} regions {of the|from the|in the|on the|with the|of your} brain. Ursocholic acid Purity 94-75-7 web PMID:23618405
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