Vitamin D {is a|is really a|is actually a|can be a|is often a|is usually a} group of seco-steroids with diverse bioactivities. An {enormous|huge|massive} {amount|quantity} of {effort|work} was expended by medicinalchemists to {search for|look for} Vitamin D analogs that could exhibit pro-differentiating and antiproliferative effects on {normal|regular|typical|standard} and cancer cells {as well|also|too|at the same time} as immunomodulatory effects {without|with out|without having|with no|devoid of|without the need of} causing hypercalcemia. A convergent {approach|method|strategy} for the total synthesis of calcipotriol (brand name: Dovonex), a {proven|confirmed|verified|established} Vitamin D analog {used|utilized|employed|utilised|applied|made use of} for the {treatment|therapy|remedy} of psoriasis, and medicinally relevant synthetic analogs is described. {Given|Offered|Provided} the {rich|wealthy} synthetic history {of the|from the|in the|on the|with the|of your} Vitamin D {family|family members|loved ones|household}, a {complete|total|full|comprehensive} novel {approach|method|strategy} towards {both|each} the A-ring and CD-ring is reported. From a retrosynthetic standpoint, hidden symmetry {within the|inside the} decorated A-ring is disclosed, which {allowed|permitted} for scalable quantities of this {advanced|sophisticated} intermediate. {In addition|Additionally|Furthermore|Moreover|Also}, a radical retrosynthetic {approach|method|strategy} is described, which highlights an electrochemical reductive coupling {as well|also|too|at the same time} as an intramolecular hydrogen atom transfer (HAT)-Giese addition to establish the {6|six},5-trans-carbon skeleton {found|discovered|identified|located} {in the|within the|inside the} Vitamin D {family|family members|loved ones|household}. Lastly, a late-stage decarboxylative cross-coupling {approach|method|strategy} {allowed|permitted} for the facile preparation of {various|numerous|different|a variety of|several|many} C20-arylated derivatives which show promising biological activity in an early bioassay. 1445951-89-2 Chemical name 2411405-92-8 manufacturer PMID:22664133
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