{Recent|Current} {research|study|analysis|investigation} in medicinal chemistry suggests a correlation {between|in between|among|amongst|involving} {an increase|a rise} {in the|within the|inside the} fraction of sp3 carbons in drug candidates with their {improved|enhanced} {success|achievement|good results|accomplishment|results} {rate|price} in clinical trials. As such, the {development|improvement} of robust and selective {methods|techniques|strategies|approaches|procedures|solutions} for the {construction|building} of C(sp3)-C(sp3) bonds remains a {critical|crucial|vital|essential|important} {problem|issue|difficulty|dilemma|challenge|trouble} in {modern|contemporary|modern day} organic chemistry. Owing {to the|towards the|for the} broad availability and synthetic accessibility of alkyl halides, their direct cross coupling—commonly {known as|referred to as|called|generally known as} cross-electrophile coupling (XEC)—provides a promising route toward this objective. {However|Nevertheless|Nonetheless|Even so|On the other hand|Having said that}, {achieving|reaching|attaining} {high|higher} selectivity in C(sp3)-C(sp3) XEC remains a largely unmet challenge. Herein, we employ electrochemistry {to achieve|to attain} the differential activation of alkyl halides by exploiting their disparate electronic and steric properties. {Specifically|Particularly|Especially}, the selective cathodic reduction of a {more|much more|a lot more|far more|additional|extra} substituted alkyl halide {gives|provides|offers} rise to a carbanion, which undergoes preferential coupling {with a|having a|using a} {less|much less|significantly less} substituted alkyl halide {via|by way of|through|by means of} bimolecular nucleophilic substitution (SN2) to forge {a new|a brand new} C–C bond. This transition-metal {free|totally free|free of charge|cost-free|absolutely free|no cost} protocol enables the {efficient|effective} XEC of {a variety of|a number of|many different|various|a range of|several different} functionalized and unactivated alkyl electrophiles and exhibits substantially {improved|enhanced} chemoselectivity versus {existing|current} methodologies. 4-Bromothiazolo[5,4-c]pyridin-2-amine site Formula of 168892-66-8 PMID:23554582
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