A stereoselective aminoiodination of activated alkynes withPhI(OAc){2|two} and amines {via|by way of|through|by means of} multiple-sitefunctionalization to afford (Z)diethyl2-(diphenylamino)-3-iodomaleate derivatives with superior yields has been described.The {key|important|crucial|essential} {feature|function} of this reaction {is the|will be the|may be the|would be the|could be the|is definitely the} incorporation of iodideand aryl group concurrently {in the|within the|inside the} {same|exact same|identical|very same|similar} molecule {in a|inside a|within a} stereoselective manner byemploying PhI(OAc)2as electrophilic reagent {as well|also|too|at the same time} as iodide and aryl group {source|supply}. Thehigh stereoselectivity {of the|from the|in the|on the|with the|of your} reaction {can be|may be|could be|might be|is often|is usually} explained {based on|according to|depending on|determined by} the structureof the {possible|feasible|achievable|attainable|doable|probable} intermediates, the conformations of which controlled by thehydrogen bonding, steric hindrance and electrostatic attractions. Thisreaction proceeds {under|below|beneath} mild {conditions|circumstances|situations}, {providing|supplying|offering|delivering|giving} {various|numerous|different|a variety of|several|many} dialkyl2-(diphenylamino)-3-iodomaleates by a single operation startingfrom activated alkynes. The robustness of our {strategy|technique|method|approach|tactic} is revealed by {making|creating|producing|generating} ofbis (dialkyl 2-(diphenylamino)-3-iodomaleate) derivatives involving formationof {four|4} new C-N bonds and two C-I bonds {with a|having a|using a} single step. The synthesizedinactive 3° enamines (dialkyl2-(diphenylamino)-3-iodomaleates) {could be|might be|could possibly be|may be|may very well be} {further|additional} transformedinto {highly|extremely|very|hugely} substituted indoles {via|by way of|through|by means of} Pdcatalyzed C-H and C-I activation {under|below|beneath} non-acidic {conditions|circumstances|situations}. Boc-NH-C6-Br Purity 2-Bromo-3-fluoropyridin-4-amine structure PMID:23557924
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