Structure-function relation is a 155 year old concept to explain the dependence of biological activity of a drug molecule on its structure put forward by Crum-Brown and Fraser*. Similar line of interest is followed in the present work, and it stimulates the understanding of structure-activity relation (SAR) among the graduate students. An attempt is made for the first time from our laboratory to apply the Hammett and Taft equations to a five membered ring system with four nitrogens as heteroatoms viz. tetrazole to identify the aqueous medium 1H and 2H Tautomers. For this purpose experimentally determined aqueous medium pKa values of NH-acidities of a total of fifteen 5-X-1,2,3,4-tetrazoles and DFT/B3LYP method at the 6-31G* level calculated dipole moments of seven 1H and 2H tautomers of 5-X-1,2,3,4-tetrazoles are used to correlate with Hammett ?para and ?meta, and Taft ?_ortho^* values. Good correlations are obtained. The promising response of more abundant and more polar 1H tautomer with less susceptibility (?* = -1.38 in pKa correlations and ?* = -0.55 in dipole moments correlation) to Taft equation and less abundant and less polar 2H tautomer with more susceptibility (?para = 6.56, ?meta = 7.79 in pKa correlations, and ?para = 2.69, ?meta = 3.26 in dipole moments correlation) to Hammett equation of the tetrazole is well distinguished. Thus it mimics a principle of structure-function study on a chemical property like the ionization of NH proton of tetrazole and on a physical property like dipole moment for the first time. Therefore finding a way is achieved to get the equilibrium identification of 1H and 2H tautomers without using any expensive and time consuming experimental techniques. 1H,1’H-4,4′-Bipyrazole supplier 2-Amino-2-thiazolin-5-one web PMID:24818938
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