An unprecedented amino-group assisted C–H carboxylation of 2-arylanilines with CO2 {under|below|beneath} redox-neutral {conditions|circumstances|situations} {using|utilizing|making use of|employing|working with|applying} a Rhodium(I)-catalyst has been {developed|created}. This reaction was promoted by a phosphine ligand with t-BuOK {as the|because the} base and {did not|didn’t} {require|need|demand|call for} {the use of|the usage of} an {extra|additional|added|further} {strong|powerful|robust|sturdy} organometallic reagent. Notably, this protocol {may|might|could|may possibly|may well|may perhaps} involve an oxidative addition {in the|within the|inside the} C–H bond cleavage step and is distinct from {previous|prior|earlier|preceding} Rh(I) or Rh(II)-catalysed {methods|techniques|strategies|approaches|procedures|solutions} for C–H carboxylation with CO2 mechanistically. It enabled an {efficient|effective} direct conversion of a broad {range of|selection of|array of} 2-(hetero)arylanilines {including|such as|which includes|like} electron-deficient heteroarenes to {various|numerous|different|a variety of|several|many} phenanthridinones, which {could be|might be|could possibly be|may be|may very well be} {further|additional} transformed to other synthetically {useful|helpful|beneficial|valuable} compounds readily. Preliminary mechanistic {studies|research} {were|had been|have been} carried out and {possible|feasible|achievable|attainable|doable|probable} intermediates {of the|from the|in the|on the|with the|of your} reaction {were|had been|have been} evaluated, which revealed that the Rh(I)-catalyst {is essential|is crucial} for the C–H activation {process|procedure|method|approach|course of action}, {providing|supplying|offering|delivering|giving} a promising {general|common|basic} {type|kind|sort|variety|form} of {method|technique|approach|strategy|system|process} for utilization of CO2 for C–C bond formation. Price of 4,4′-Di-tert-butyl-2,2′-bipyridine 1538623-41-4 structure PMID:33679749
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