{In the|Within the|Inside the} {current|present|existing} {work|function|perform|operate}, we present a {combination|mixture} of {various|numerous|different|a variety of|several|many} classical and quantum computational protocols to unveil the molecular mechanism of FAD protonation in E. coli photolyase and its mutant. A direct comparison to our {previous|prior|earlier|preceding} study {on the|around the} plant cryptochrome clearly shows the {great|fantastic|excellent|wonderful|good|terrific} influence {of the|from the|in the|on the|with the|of your} electrostatic {environment|atmosphere} {and the|and also the|as well as the|along with the|plus the} flexibility {of the|from the|in the|on the|with the|of your} FAD pocket {on the|around the} proton transfer mechanism. {Additionally|In addition|Furthermore|Moreover|Also|On top of that}, we propose a proton transfer pathway for WT E. coli photolyase {consistent|constant} with experimental observations. Taken {together|with each other|collectively}, our {results|outcomes|final results|benefits} and {previous|prior|earlier|preceding} experimental {data|information} {provide|offer|supply|give|present|deliver} a {comprehensive|complete|extensive} {picture|image} {about the|concerning the|regarding the|in regards to the} functional differentiation {in the|within the|inside the} cryptochrome-photolyase {family|family members|loved ones|household}. 109705-14-8 Chemscene BuyTaltobulin intermediate-1 PMID:28038441
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