A catalytic {system|method|program|technique} was {discovered|found} for the intramolecular C-H amidation of N-phenoxy acetamide derivatives. For {the first|the very first|the initial} time, a cobalt catalyst was employed for the Catellani reaction. {Additionally|In addition|Furthermore|Moreover|Also|On top of that}, a monocyclic olefin, maleimide, was {used|utilized|employed|utilised|applied|made use of} as a transient mediator in {place|location|spot} of bicyclic norbornenes. Maleimide promotes a Co(III) intermediate to undergo oxidative addition {into the|in to the} O–N bond to {form|type|kind} a Co(V) nitrene species and subsequently directs nitrene addition {to the|towards the|for the} ortho position. A plausible mechanism for the transformation is proposed, supported by experimental and density functional theory (DFT) computational {studies|research}. {Further|Additional}, the synthetic utility of this methodology was demonstrated {via|by way of|through|by means of} the ortho-amidation of estrone. 1228875-16-8 site Buy116700-73-3 PMID:27641997
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