We report a perfluorophenylboronic acid catalyzed cross coupling reaction of tertiary propargylic alcohols and hetero-areneboronic acids for {valuable|beneficial|useful|worthwhile|precious|important} benzo[b]thiophene and cyclopenta[a]indene derivates. This coupling reaction proceeds {efficiently|effectively} {with a|having a|using a} wide array of substrates scope in {up to|as much as} 89% yield and {excellent|superb|outstanding|exceptional|great|fantastic} regioselectivity. A {significant|substantial|considerable|important} {advantage|benefit} of our protocol {is the|will be the|may be the|would be the|could be the|is definitely the} transition metal catalyst {free|totally free|free of charge|cost-free|absolutely free|no cost} and mild {conditions|circumstances|situations} {needed|required|necessary}. This {strategy|technique|method|approach|tactic} {provides|offers|gives|supplies|delivers} direct and facile access to medicinally {important|essential|crucial|critical|significant|vital} benzo[b]thiophene and cyclopenta[a]indene scaffold containing a quaternary carbon center. (R)-2-Methylazetidine hydrochloride Data Sheet Buy3-Bromo-2-iodobenzo[b]thiophene PMID:24238102
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