Carbon-fluorine bond activation reaction {of the|from the|in the|on the|with the|of your} trifluoromethyl group represent {an important|an essential|a crucial|a vital} {approach|method|strategy} to fluorine-containing molecules. {While|Whilst|Although|Even though|When|Though} selective defluorofunctionalization reactions of CF3-containing substrates {have been|happen to be|have already been} {achieved|accomplished} by invoking difluorocarbocation, difluorocarboradical, or difluoroorganometallic species {as the|because the} {key|important|crucial|essential} intermedi-ate, the transformations {via|by way of|through|by means of} fluorocarbanion mechanism remained a {limited|restricted} {success|achievement|good results|accomplishment|results}. {Furthermore|Moreover|In addition|Additionally}, the enantioselective defluorotransformation of CF3 group has not {yet|however|but} been realized. Herein, we report a defluorofunctionalization reaction of 4-trifluoromethylpyridines involving pyridyldifluoromethyl anion {as the|because the} {key|important|crucial|essential} intermediate, which was {developed|created} {based|primarily based} upon our {previous|prior|earlier|preceding} {studies|research} {on the|around the} N-boryl pyridyl anion chemistry. When combined with Ir-catalysis, asymmetric defluoroallylation of 4-trifluoromethylpyridines {could be|might be|could possibly be|may be|may very well be} {achieved|accomplished} to forge a difluoroalkyl-substituted chiral center. The present {work|function|perform|operate} opens up {a new|a brand new} {opportunity|chance} for the defluorofunctionalization of CF3 group, and {provides|offers|gives|supplies|delivers} new insights {into the|in to the} N-boryl pyridyl anion chemistry. 2,2-Oxybis(ethylamine) manufacturer 1319716-42-1 web PMID:34816786
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