Hydrogen peroxide (H2O2) plays {an important|an essential|a crucial|a vital} {role|function|part} in {various|numerous|different|a variety of|several|many} signal transduction pathways and regulates {important|essential|crucial|critical|significant|vital} cellular processes. {However|Nevertheless|Nonetheless|Even so|On the other hand|Having said that}, monitoring and quantitatively assessing the distribution of H2O2 molecules inside living cells {requires|demands|needs|calls for} a nanoscale sensor with molecular-level sensitivity. Herein, we show {the first|the very first|the initial} demonstration of sub-10 nm-sized fluorescent nanodiamonds as a catalyst for the decomposition of H2O2 {and the|and also the|as well as the|along with the|plus the} production of radical intermediates {at the|in the} nanoscale. {Furthermore|Moreover|In addition|Additionally}, the NV quantum sensors inside the nanodiamonds are employed to quantify the aforementioned radicals. We {believe|think} that our {method|technique|approach|strategy|system|process} of combining the peroxidase-mimicking activities {of the|from the|in the|on the|with the|of your} nanodiamonds with their intrinsic quantum sensor showcases their application as a self-reporting H2O2 sensor with molecular-level sensitivity and nanoscale spatial resolution. {Given|Offered|Provided} the robustness {and the|and also the|as well as the|along with the|plus the} specificity {of the|from the|in the|on the|with the|of your} sensor, our {results|outcomes|final results|benefits} {promise|guarantee} {a new|a brand new} platform for elucidating the {role|function|part} of H2O2 {at the|in the} cellular level. 3-Hydroxypyridine-2-carboxaldehyde supplier Buy(3-Cyclopropylphenyl)boronic acid PMID:24507727
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