We report the {development|improvement} of an unprecedented metal-free four-step one-pot synthetic {strategy|technique|method|approach|tactic} to access high-value functionalized phthalazines {using|utilizing|making use of|employing|working with|applying} o-methyl benzophenones as {starting|beginning} compounds. {Combination|Mixture} of a light-mediated enolization of o-methyl benzophenones/Diels-Alder reaction domino {process|procedure|method|approach|course of action} {with a|having a|using a} subsequent deprotection/aromatization domino reaction in one-pot {leads to|results in} sustainable and {efficient|effective} organic synthesis. The tangible {advantages|benefits|positive aspects}, i.e. absence of catalysts or additives, utilization of commercially {available|accessible|obtainable|offered|readily available|out there} and/or {easily|effortlessly|very easily|simply|quickly|conveniently} accessible substrates, mild reaction {conditions|circumstances|situations}, simplicity, and single work-up {procedure|process}, make this combined {process|procedure|method|approach|course of action} {highly|extremely|very|hugely} {appealing|attractive} for the direct {construction|building} of {various|numerous|different|a variety of|several|many} 1-aryl-phthalazines. (2-Hydroxyethyl)trimethylsilane Formula Formula of Z-Asp(OtBu)-OH PMID:35991869
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